SITS Publications

This is a list of all publications carried out in collaboration with SITS

55. Scheitz JF, Abdul-Rahim AH, MacIsaac RL, Cooray C, Sucharew H, Kleindorfer D, Khatri, P, Brod- erick JP, Audebert HJ, Ahmed N, Wahlgren N, Endres M, Nolte CH, Lees KR. Clinical selection strategies to identify stroke patients with large anterior vessel occlusion-Results from SITS-ISTR. (Stroke, In press December 2016). PubMed PMID: 28087804. [PubMed]

54. Cooray C, Mazya M, Bottai M, Dorado L, Skoda O, Toni D, Ford GA, Wahlgren N, Ahmed N. External Validation of the ASTRAL and DRAGON Scores for Prediction of Functional Outcome in Stroke. Stroke. 2016 Jun;47(6):1493-9. PubMed PMID: 27174528[PubMed]

 

53. Ahmed N, Hermansson K, Bluhmki E, Danays T, Nunes AP, Kenton A, Lakshmanan S, Toni D, Mikulik R, Ford GA, Lees KR and Wahlgren N. The SITS-UTMOST: A registry-based prospective study in Europe investigating the impact of regulatory approval of intravenous Actilyse in the extended time window (3–4.5 h) in acute ischaemic stroke. European Stroke Journal, first published on July 29, 2016 doi:10.1177/2396987316661890. [European Stroke Journal]

52. Lundström E, Zini A, Wahlgren N, Ahmed N. How common is isolated dysphasia among patients with stroke treated with intravenous thrombolysis, and what is their outcome? Results from the SITS-ISTR. BMJ Open. 2015 Nov 25;5(11):e009109. doi: 10.1136/ bmjopen 2015-009109. PubMed PMID: 26608637. [PubMed]  

51. Anani N, Mazya MV, Bill O, Chen R, Koch S, Ahmed N, Wahlgren N, Prazeres Moreira T. Changes in European Label and Guideline Adherence After Updated Recommendations for Stroke Thrombolysis: Results From the Safe Implementation of Treatments in Stroke Registry. Circ Cardiovasc Qual Outcomes. 2015 Oct;8(6 Suppl 3): S155-62. doi: 10.1161/CIRCOUTCOMES.115.002097. PubMed PMID: 26515204. [PubMed]

50. Mazya MV, Lees KR, Collas D, Rand VM, Mikulik R, Toni D, Wahlgren N, Ahmed N. IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry. Neurology. 2015 Nov 6. pii: 10.1212/WNL.0000000000002199.
[Epub ahead of print]. PubMed PMID: 26546630. [PubMed]

49. Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Gdovinova Z, Švigelj V, Csiba L, Fekete K, Kõrv J, Demarin V, Bašic-Kes V, Vilionskis A, Jatuzis D, Krespi Y, Shamalov N, Andonova S, Ahmed N, Wahlgren N; Safe Implementation of Treatments in Stroke–East Registry (SITS-EAST) Investigators. Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event. Stroke. 2015 Oct 8. pii: STROKEAHA.115.010420. [Epub ahead of print]. PubMed PMID: 26451024. [PubMed]

48. Abdul-Rahim AH, Fulton RL, Sucharew H, Kleindorfer D, Khatri P, Broderick JP, Lees KR; SITS-MOST Steering Committee. National Institutes of Health Stroke Scale Item Profiles as Predictor of Patient Outcome: External Validation on Safe Implementation of Thrombolysis in Stroke-Monitoring Study Data. Stroke. 2015 Oct;46(10):2779-85. doi: 10.1161/STROKEAHA.115.010380. Epub 2015 Sep 10. PubMed PMID: 26359360. [PubMed]

47. Tsivgoulis G, Kadlecová P, Kobayashi A, Czlonkowska A, Brozman M, Švigelj V, Csiba L, Kõrv J, Demarin V, Vilionskis A, Jatuzis D, Katsanos AH, Rudolf J, Krespi Y, Mikulik R. Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke. Stroke. 2015 Sep;46(9):2681-4. doi: 10.1161/STROKEAHA.115.010244. Epub 2015 Jul 14. PubMed PMID: 26173726. [PubMed]

46. Flint AC, Rao VA, Chan SL, Cullen SP, Faigeles BS, Smith WS, Bath PM, Wahlgren N, Ahmed N, Donnan GA, Johnston SC; SITS International and VISTA-plus investigators. Improved ischemic stroke outcome prediction using model estimation of outcome probability: the THRIVE-c calculation. Int J Stroke. 2015 Aug;10(6):815-21. doi: 10.1111/ijs.12529. Epub 2015 Jun 4. PubMed PMID: 26045081. [PubMed]

45. Cooray C, Fekete K, Mikulik R, Lees KR, Wahlgren N, Ahmed N. Threshold for NIH stroke scale in predicting vessel occlusion and functional outcome after stroke thrombolysis. Int J Stroke. 2015 Aug;10(6):822-9. doi: 10.1111/ijs.12451. Epub 2015 Jan 15. PubMed PMID: 25588617. [PubMed]

44. Strbian D, Ahmed N, Wahlgren N, Lees KR, Toni D, Roffe C, Surakka IL, Tatlisumak T; SITS Investigators. Trends in Door-to-Thrombolysis Time in the Safe Implementation of Stroke Thrombolysis Registry: Effect of Center Volume and Duration of Registry Membership. Stroke. 2015 May;46(5):1275-80. doi: 10.1161/STROKEAHA.114.007170. Epub 2015 Mar 31. PubMed PMID: 25828238. [PubMed]

43. Novotná J, Kadlecová P, Czlonkowska A, Brozman M, Švigelj V, Csiba L, Kõrv J, Demarin V, Vilionskis A, Mikulík R; SITS-EAST Investigators. Hyperdense cerebral artery computed tomography sign is associated with stroke severity rather than stroke subtype. J Stroke Cerebrovasc Dis. 2014 Nov-Dec;23(10):2533-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.04.034. Epub 2014 Sep 27. PubMed PMID: 25267589. [PubMed]

42. Haršány M, Kadlecová P, Švigelj V, Kõrv J, Kes VB, Vilionskis A, Krespi Y, Mikulík R; SITS-EAST Investigators. Factors influencing door-to-imaging time: analysis of the safe implementation of treatments in Stroke-EAST registry. J Stroke Cerebrovasc Dis. 2014 Sep;23(8):2122-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.03.019. Epub 2014 Aug 6. PubMed PMID: 25106830. [PubMed]

41. Flint AC, Gupta R, Smith WS, Kamel H, Faigeles BS, Cullen SP, Rao VA, Bath PM, Wahlgren N, Ahmed N, Donnan GA; SITS International and VISTA-plus investigators. The THRIVE score predicts symptomatic intracerebral hemorrhage after intravenous tPA administration in SITS-MOST. Int J Stroke. 2014 Aug;9(6):705-10. doi: 10.1111/ijs.12335. Epub 2014 Jul 15. PubMed PMID: 25042855. [PubMed]

40. Mazya MV, Ahmed N, Ford GA, Hobohm C, Mikulik R, Nunes AP, Wahlgren N. Remote or extraischemic intracerebral hemorrhage-an uncommon complication of stroke thrombolysis: results from the safe implementation of treatments in stroke-international stroke thrombolysis register. Stroke. 2014 Jun;45(6):1657-63. doi: 10.1161/STROKEAHA.114.004923. Epub 2014 May 1. PubMed PMID: 24788971. [PubMed]

39. Karlinski M, Kobayashi A, Czlonkowska A, Mikulik R, Vaclavik D, Brozman M, Svigelj V, Csiba L, Fekete K, Kõrv J, Demarin V, Vilionskis A, Jatuzis D, Krespi Y, Ahmed N, Wahlgren N; for the Safe Implementation of Treatments in Stroke–Eastern Europe (SITS-EAST) Investigators; Countries participating in SITS-EAST with national coordinators and number of cases contributed. Role of Preexisting Disability in Patients Treated With Intravenous Thrombolysis for Ischemic Stroke. Stroke. 2014 Feb 4. [Epub ahead of print]. PubMed PMID: 24496395. [PubMed]

38. Lorenzano S, Ahmed N, Tatlisumak T, Gomis M, Dávalos A, Mikulik R, Sevcik P, Ollikainen J, Wahlgren N, Toni D; SITS Investigators. Within-day and weekly variations of thrombolysis in acute ischemic stroke: results from safe implementation of treatments in stroke-international stroke thrombolysis register. Stroke. 2014 Jan;45(1):176-84. doi: 10.1161/STROKEAHA.113.002133. Epub 2013 Nov 21. PubMed PMID: 24262329. [PubMed]

37. Lorenzano S, Ahmed N, Falcou A, Mikulik R, Tatlisumak T, Roffe C, Wahlgren N, Toni D; SITS Investigators. Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register. Stroke. 2013 Dec;44(12):3401-6. doi: 10.1161/STROKEAHA.113.002908. Epub 2013 Oct 30. PubMed PMID: 24172579. [PubMed]

36. Kõrv J, Vibo R, Kadlecová P, Kobayashi A, Czlonkowska A, Brozman M, Svigelj V, Csiba L, Fekete K, Demarin V, Vilionskis A, Jatuzis D, Krespi Y, Ahmed N, Mikulík R; for the Safe Implementation of Treatments in Stroke − East (SITS-EAST) Registry Investigators. Benefit of thrombolysis for stroke is maintained around the clock: results from the SITS-EAST Registry. Eur J Neurol. 2013 Sep 16. doi: 10.1111/ene.12257. [Epub ahead of print]. PubMed PMID: 24102712. [PubMed]

35. Kharitonova TV, Melo TP, Andersen G, Egido JA, Castillo J, Wahlgren N; SITS investigators. Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis. Stroke. 2013 Sep;44(9):2513-8. doi: 10.1161/STROKEAHA.111.000048. Epub 2013 Jul 23. PubMed PMID: 23881960. [PubMed]

34. Mazya MV, Lees KR, Markus R, Roine RO, Seet RC, Wahlgren N, Ahmed N; for the SITS investigators. Safety of IV thrombolysis for ischemic stroke in patients treated with warfarin. Ann Neurol. 2013 Jun 6. doi: 10.1002/ana.23924. [Epub ahead of print]. PubMed PMID: 23744571. [PubMed]

33. Ahmed N, Kellert L, Lees KR, Mikulik R, Tatlisumak T, Toni D; for the SITS Investigators. Results of Intravenous Thrombolysis Within 4.5 to 6 Hours and Updated Results Within 3 to 4.5 Hours of Onset of Acute Ischemic Stroke Recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): An Observational Study. JAMA Neurol. 2013 May 20:1-8. doi: 10.1001/jamaneurol.2013.406. [Epub ahead of print]. PubMed PMID: 23689267. [PubMed]

32. Mazya MV, Bovi P, Castillo J, Jatuzis D, Kobayashi A, Wahlgren N, Ahmed N. External Validation of the SEDAN Score for Prediction of Intracerebral Hemorrhage in Stroke Thrombolysis. Stroke. 2013 Jun;44(6):1595-600. doi: 10.1161/STROKEAHA.113.000794. Epub 2013 Apr 30. PubMed PMID: 23632975. [PubMed]

31. Rha JH, Shrivastava VP, Wang Y, Lee KE, Ahmed N, Bluhmki E, Hermansson K, Wahlgren N, for the SITS investigators. Thrombolysis for acute ischemic stroke with alteplase in an Asian population: results of the multicenter, multinational, Safe Implementation of Thrombolysis in Stroke-Non European Union World (SITS-NEW). In J Stroke 2012, Epub 2012 Sep 18. PubMed PMID:25588617.[PubMed]

30. Strbian D, Ahmed N, Wahlgren N, Kaste M, Tatlisumak T, for SITS investigators. Intravenous thrombolysis in ischemic stroke patients with isolated homonymous hemianopia: analysis of Safe Implementation of Thrombolysis in Stroke - International Stroke Thrombolysis Register (SITS-ISTR). Stroek 2012; 43: 2695-2698, Epub 2012 Jul 17. PubMed PMID:22811459. [PubMed]   

29. Mazya M, Egido J, Ford G, Lees K, Mikulik R, Toni D, Wahlgren N, Ahmed N; For the SITS investigators. Predicting the Risk of Symptomatic Intracerebral Hemorrhage in Ischemic Stroke Treated With Intravenous Alteplase: Safe Implementation of Treatments in Stroke (SITS) Symptomatic Intracerebral Hemorrhage Risk Score. Stroke 2012; 43:1524-1531, Epub 2012 March 22. PubMed PMID:22442178. [PubMed] 

28. Mikulík R, Kadlecová P, Czlonkowska A, Kobayashi A, Brozman M, Svigelj V, Csiba L, Fekete K, Kõrv J, Demarin V, Vilionskis A, Jatuzis D, Krespi Y, Ahmed N; for the Safe Implementation of Treatments in Stroke-East Registry (SITS-EAST) Investigators. Factors Influencing In-Hospital Delay in Treatment With Intravenous Thrombolysis. Stroke. 2012 Mar 15. [Epub ahead of print]

27. Karlinski M, Kobayashi A, Mikulik R, Sanak D, Wahlgren N, Czlonkowska A. Intravenous alteplase in ischemic stroke patients not fully adhering to the current drug license in Central and Eastern Europe. Int J Stroke. 2012 Feb 7. doi: 10.1111/j.1747-4949.2011.00733.x. [Epub ahead of print]

26. Toni D, Ahmed N, Anzini A, Lorenzano S, Brozman M, Kaste M, Mikulik R, Putaala J, Wahlgren N; For the SITS investigators. Intravenous thrombolysis in young stroke patients: Results from the SITS-ISTR. Neurology. 2012 Mar 7. [Epub ahead of print]

25. Mishra NK, Ahmed N, Davalos A, Iversen HK, Melo T, Soinne L, Wahlgren N, Lees KR; SITS and VISTA collaborators. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology. 2011 Nov 22;77(21):1866-72. Epub 2011 Nov 16. PubMed PMID: 22094479. [PubMed - indexed for MEDLINE]

24. Zinkstok SM, Vergouwen MD, Engelter ST, Lyrer PA, Bonati LH, Arnold M, Mattle HP, Fischer U, Sarikaya H, Baumgartner RW, Georgiadis D, Odier C, Michel P, Putaala J, Griebe M, Wahlgren N, Ahmed N, van Geloven N, de Haan RJ, Nederkoorn PJ. Safety and functional outcome of thrombolysis in dissection-related ischemic stroke: a meta-analysis of individual patient data. Stroke. 2011 Sep;42(9):2515-20. Epub 2011 Jul 28. Review. [PubMed]

23. Kharitonova T, Mikulik R, Roine RO, Soinne L, Ahmed N, Wahlgren N; for the Safe Implementation of Thrombolysis in Stroke (SITS) Investigators. Association of Early National Institutes of Health Stroke Scale Improvement With Vessel Recanalization and Functional Outcome After Intravenous Thrombolysis in Ischemic Stroke. Stroke. 2011 Jun;42(6):1638-43. Epub 2011 Apr 21. [PubMed]

22. Diedler J, Ahmed N, Glahn J, Grond M, Lorenzano S, Brozman M, Sykora M, Ringleb P. Is the Maximum Dose of 90 mg Alterplase Sufficient for Patients With Ischemic Stroke Weighing > 100 kg? Stroke. 2011 Jun;42(6):1615-20. Epub 2011 Apr 14. [PubMed]

21. Topakian R, Brainin M, Eckhardt R, Kiechl S, Ahmed N, Ferrari J, Iglseder B, Wahlgren NG, Lang W, Fazekas F, Willeit J, Aichner FT; for the SITS-Austria group. Thrombolytic therapy for acute stroke in Austria: data from the Safe Implementation of Thrombolysis in Stroke (SITS) register. Eur J Neurol. 2011 Feb;18(2):306-11. [PubMed]

20. Mishra, NK, Ahmed N, Andersen G, Egido J, Lindsberg P, Ringleb PA, Wahlgren N, Lees KR for the VISTA and SITS collaborators. Thrombolysis in the very elderly: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive. BMJ. 2010 Nov 23;341:c6046. [PubMed]

19. Ford GA, Ahmed N, Azevedo E, Grond M, Larrue V, Lindsberg P, Toni D, Wahlgren N. Intravenous alteplase for stroke in those older than 80 years old. Stroke. 2010 Nov;41(11):2568-74. Epub 2010 Oct 7. [PubMed]

18. Ahmed N, Wahlgren N, Grond M, Hennerici M, Lees KR, Mikulik R, Parsons M, Roine RO, Toni D, Ringleb P, for the SITS Investigators. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR. Lancet Neurol 2010; 9; 866-74. [PubMed]

17. Ahmed N, Dávalos A, Eriksson N, Ford GA, Glahn J, Hennerici M, Mikulik R, Kaste M, Lees KR, Lindsberg P, Toni D, for the SITS Investigators. Association of admission blood glucose and outcome in patients treated with intravenous thrmbolysis. Arch Neurol 201; 67(9): 1123-1130. [PubMed]

16. Diedler J, Ahmed N, Sykora M, Uyttenboogaart M, Overgaard K, Luijckx G-J, Soinne L, Ford GA, Lees KR, Wahlgren N, Ringleb P. Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset. Stroke. 2010 Feb;41(2):288-94. Epub 2010 Jan 7. [PubMed]

15. Simpson MA, Dewey HM, Churilov L, Ahmed N, Bladin CF, Schultz D, Mrkus R, Stur JW, Levi CR, Blacker DJ, Jannes J, Lindley RI, Parsons MW. Thrombolysis for acute stroke in Australia: outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002-2008). Med J.Aust 2010 Oct 18;193(8):439-43. [PubMed]

14. Vanacker P, Thijs V, Peeters A, BruneelB, Laloux P, Druwé P, De DeynP, Ahmed N, Wahlgren N, Vanhooren G; Belgian SITS-collaboration group. The Belgian experience with intravenous thrombolysis for acute ischemic stroke. Acta Neurol Belg. 2010 Jun;110(2):157-62. [PubMed]

13. Wahlgren N. Systemic thrombolysis in clincal practice: what have we learned after the Safe Implementation of Thrombolysis in Stroke Monitoring Study? Cerebrovasc Dis. 2009;27 Suppl 1:168-76. Epub 2009 Apr 3. Review. [PubMed]

12. Kharitonova T, Ahmed N, Thoren M, et al. Hyperdense middle cerebral artery sign on admission CT scan - prognostic significance for ischaemic stroke patients treated with intravenous thrombolysis in the safe implementation of thrombolysis in Stroke. International Stroke Thrombolysis Register. Cerebrovasc Dis. 2009;27(1):51-9. Epub 2008 Nov 15. [PubMed]

11. Mikulík R, Václavík D, Sanák D, Bar M, Sevcík P, Kalita Z, Wahlgren N. A nationwide study on topography and efficacy of the stroke treatment network in the Czech republic. J Neurol. 2010 Jan;257(1):31-7. Epub 2009 Jul 23. [PubMed]***

10. Kharitonova T, Thorén M, Ahmed N, Wardlaw JM, von Kummer R, Thomassen L, Wahlgren N, for the SITS investigators. Disappearing Hyperdense Middle Cerebral Artery Sign in ischemic stroke patients treated. J Neurol Neurosurg Psychiatry. 2009 Mar;80(3):248. Epub 2008 Oct 17. [PubMed]

09. Kobayashi A, Czlonkowska A, Ahmed N, Romanowicz S, Glonek M, Nyka WM, Opala G, Wahlgren N; for the SITS Poland Collaborative Group. Intravenous recombinant tissue plasminogen activator for acute stroke in Poland: an analysis based on the Safe Implementation of Thrombolysis in Stroke (SITS) Registry. Acta Neurol Scand. 2010 Oct;122(4):229-36. [PubMed]

08. Roje-Bedeković M, Vargek-Solter V, Corić L, Sabolek K, Breitenfeld T, Supanc V, Demarin V. Thrombolysis for acute ischemic stroke--our experiences as part of SITS-MOST. Acta Clin Croat. 2009 Sep;48(3):287-93.** [PubMed]

07. Ahmed N, Wahlgren N, Brainin M, et al. Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenious thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke - International Stroke Thrombolysis Register (SITS-ISTR). Stroke. 2009 Jul;40(7):2442-9. Epub 2009 May 21. [PubMed]

06. Rodríguez-Yáñez M, Alvarez-Sabín J, Dávalos A, Díez-Tejedor E, Castillo J. Thrombolytic therapy for acute ischemic stroke. Experience of SITS (Safe Implementation of Thrombolysis in Stroke) register. Neurologia. 2009 Jun;24(5):288-91. Spanish.* [PubMed]

05. Lorenzano S, Ahmed N, Rosselli A, Marcello N, Inzitari D, Sterzi R, Wahlgren N, Prencipe M, Toni D. Safe implementation of thrombolysis in stroke-monitoring study in Italy. Eur J Neurol. 2010 Jan;17(1):163-7.Jun 15. [Epub ahead of print June 2009]. [PubMed]

04. Wahlgren N, Ahmed N, Dávalos A, Hacke W, Millán M, Muir K, Roine RO, Toni D, Lees KR. Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet 2008; 372: 1303-1309. [PubMed]

03. Lees KR, Ford GA, Muir KW, Ahmed N, Dyker AG, Atula S, Kalra L, Warburton EA, Baron JC, Jenkinson DF, Wahlgren NG, Walters MR; SITS-UK Group. Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register. QJM. 2008 Nov;101(11):863-9. Epub 2008 Aug 11. [PubMed]

02. Wahlgren N, Ahmed A, Eriksson N, Aichner F, Bluhmki E, Dávalos A, Erilä T, Ford GA, Grond M, Hacke W, Hennerici M, Kaste M, Köhrmann M, Larrue V, Lees KR, Machnig T, Roine RO, Toni D, Vanhooren G, for the SITS-MOST investigators. Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials; Safe Implementation of Thrombolysis in Stroke Monitoring Study (SITS-MOST). Stroke 2008; 39: 3316-3322. [PubMed]

01. Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Külkens S, Larrue V, Lees KR, Roine RO, Soinne L, Toni D, Vanhooren G: Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet 2007;369:275-282. [PubMed]

 

* Published independently by the Spanish group.
** Published independently by the Croatian group.
*** This paper is including data from SITS but also data collected for a wider group of patients than iv thrombolysis.